Trovatelli/Acocella

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Phd Student: Marco Trovatelli

Marco Trovatelli graduated in Veterinary Medicine at the University of Milan in February 2016, with thesis entitled “Evaluation of the depth of penetration into abdominal wall of Abraxane after hyperthermic intraperitoneal administration (HIPEC) in rabbit”. He obtained the medical habilitation to professional practice in June 2016. During his university course he performed an internship at Veterinary Teaching Hospital of Università degli Studi di Milano, Surgical division. He participated, like official visitor, in a multi organ transplant procedure from a brain death patient at Spedali Civili di Brescia of Università degli Studi di Brescia, 3^ General Surgical division. His main interest fields are in surgery and experimental medicine. Now he is working at the Unit of Veterinary Surgery, Department of Health, Animal Science and Food Safety where he started a PhD program in October 2016 with a research project in “Animal model for minimally invasive neurosurgery”.

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Tutor: Prof. Fabio Acocella

After his degree in Veterinary Medicine at the University of Milan in 1991, Fabio Acocella obtained a PhD at University of Milan in 1998. After a period as contract professor in Anatomy of the Domestic Animals at University of Padova, he received a postdoc in fetal surgery at University of Milan from 1998 to 2002. He has been part of a teamwork to establish the Experimental Surgery Center for didactic and research at Univesité des Montagnes, Bangangté (Cameroon) in 2003-2006. He became researcher at University of Milan in 2006 and then aggregate professor in surgery until 2012. Now he is currently associate professor of Veterinary Surgery at Department of Health, Animal Science and Food Safety at University of Milan. In 2008 he has been a visiting scientist at Institute of Regenerative Medicine (Wake Forrest University, NC, USA) and in 2014 at Transplant Immunology Laboratory (Stanford, Ca, USA). His main interests are in general and thoracic surgery, regenerative medicine, experimental models in surgery and education in surgery. He is author of 26 international publication peer-review and of two book chapters in regenerative medicine area.

PROJECT DESCRIPTION:

Minimally invasive surgery has been considered a major revolutionary method in surgery. Although all the advantages and the benefits of minimally invasive surgeries, not all surgeries can be done invasively. Robotically-assisted surgery overcomes the restricted mobility problems by performing the normal surgery movements although the robotics arms in fact carry out the movement using end-effectors and manipulators to do the actual surgery on the patient. Neurosurgery has witnessed an accelerated growth in the advancement and clinical adoption of Computer Tomography (CT) and Magnetic Resonance Imaging (MRI). Diffusion tensor imaging (DTI) is a form of diffusion weighted MRI that assesses physiological water directionality and motion, providing images of important white matter tracts within the Central Nervous System (CNS). The rapid evolution in clinical approach has influenced many areas of neurosurgery but there are still diseases without a standard of care. Gliobastoma (GBM) is one of these diseases which can’t be complete neurosurgical removed. As a result, surgery must be followed by adjuvant therapy modalities like radiotherapy (RT), chemotherapy (ChT) like convection-enhanced delivery procedure (CED), or both. The procedure still suffers from significant shortcomings, like reflux, inaccurate catheter placement and limited drug distribution within the substrate at the point of delivery. The project is focused on the use of a minimally invasive approach with robotic control. Sheep, like animal model, will be used to improve the use of CED, passing the problems like damage of a rigid catheter or the inaccurate catheter placement and limited drug distribution.

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Figure 1: Diffusion tensor based images

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Figure 2: Glioblastoma multiforme