Polito/Di Giancamillo

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Phd Student: Umberto Polito

Graduated in October 2015 in Veterinary Medicine at the University of Milan discussing a thesis entitled “Morphometric configuration of the skull between different dog breeds during the first two months of life: ex vivo anatomic and radiographic study on 173 subjects”. Obtained the license to practice Veterinary Medicine in December 2015. Main interests: small animals orthopedic surgery and clinic, small animals diagnostic imaging, biomechanics, anatomy and histology.

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Tutor: Prof. Alessia Di Giancamillo

Current position: Associate professor of Veterinary Anatomy, Department VESPA, University of Milan.

Professional career: graduated in Veterinary Medicine at the University of Milan (1998); licensed to practice Veterinary Medicine (1998); Scholariship at ICRSS Istituto Carlo Besta, Milano (2000); PhD student at University of Milan (2000-2004); Research contract at University of Milan (2004-2010); Scholarship in the project “Women in Scientific Research” (2010); Research Contract at IRCCS San Raffaele, Milano (2011); Research contract at University of Milan (2011-2012); Research Contract at IRCCS Galeazzi, Milano (2012-2014). Research activities: Author and co-author of around 120 publications. Her scientific activity concerns the structural study of native and engineered chondral, meniscal, tendon and bone tissues: Co-inventor of the international patent “COMPOSITE SCAFFOLD FOR OSTHEOCONDRAL REPLACEMENT”

 

PROJECT DESCRIPTION:

The stifle is a common site of osteo-articular lesions in both human and animals. Ligament injury to the knee is more common than any other type of knee injury pathology and the Anterior Cruciate Ligament (ACL) is the most afflict ligament. ACL failure is also the most common orthopedic condition of the dog stifle and the resulting instability is usually associated to a secondary meniscal injury. For this reason, the stifle structures are often the main subjects of pathophysiology’s studies or are employed for testing new surgical solutions, devices, and engineered implants for the regeneration of these tissues, and, to implement these, a translational work in animal models is still necessary. Nevertheless, there is no animal species that can act as a perfect model for the osteo-articular human pathologies since there are interspecific differences that couldn’t be ever filled. The choice of the best model is important to reduce the passages that include animal experimentation. Before patients (human and not) can benefit from such data, a more complete knowledge of micro-anatomical, biochemical and biomechanical specific characteristics of stifle anatomy and structure is fundamental.  In addition, particular attention must be given to changes and remodeling in anatomic structures during animal growth because these information can be an important landmark for tissue engineering. For this purpose, microarchitecture and composition of the stifle’s tissues will be evaluated employing microscopic (histomorphometry, histochemistry, immunohistochemistry), diagnostic imaging techniques (traditional radiography, computed tomography, micro-computed tomography, dual-energy x-ray absorptiometry and magnetic resonance imaging) and biomechanical tests gained with appropriate machine and software will be investigated. No animals will be sacrifice for this project. Animals for the present research project will be collected after euthanasia as part of unrelated experiments, sampled at the slaughterhouse, or donated by private owner after death occurring because of incurable diseases unrelated to the osteo-articular apparatus.

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