Amedea Manfredi

Manfredi

Assistant Professor of Organic Chemistry  Expertise: organic synthesis, polymer chemistry

 

Graduated in Chemistry on 1982 at the University of Milan, appointed Researcher of the National Research Council on 1986, and Assistant Professor of Industrial Chemistry on 1992 at the Department of Organic and Industrial Chemistry (now merged into the Department of Chemistry). Her research activity has been focused, among others, on the asymmetric synthesis in biomimetic conditions (employing proteins, enzymes and cyclodextrins as chiral auxiliaries) or through the use of organometallic ligands; on the synthesis and characterization of chiral porphyrins to be used as catalysts in oxidation reactions; on the synthesis and characterization of macrocyclic and macropolycyclic receptors, and of new perfluorinated catalysts. Her present research interests are focused on the synthesis and characterization of a) biocompatible and biodegradable polymers for medical applications, to be used as: soluble or nanoparticulate carriers of antitumor, antiviral drugs or for gene therapy; b) biodegradable hydrogels as scaffolds for tissue engineering, and c) multifunctional cross-linked resins for the adsorption of heavy metal ions. She is co-author of more than 55 scientific publications in peer-reviewed International Scientific Journals, with an h-index of 14. She has been responsible lecturer of the courses of Organic Fine and Macromolecular Chemistry for the Bachelor degree in Applied and Environmental Chemistry (2002-2011) and of Safety in the Work and Chemical Instrumentations for the Bachelor degree in Industrial Chemistry (2000-2009). At present she teaches Laboratory of Industrial chemistry for the Bachelor degree in Industrial Chemistry, and Process Development for the Master degree in Industrial Chemistry.

 

 

1.  V. Magnaghi, V. Conte, P. Procacci, G. Pivato, P. Cortese, E. Cavalli, G. Pajardi, E. Ranucci, F. Fenili, A. Manfredi., P. Ferruti – Biological Performance of a Novel Biodegradabile Polyamidoamine Hydrogel as Guide for Peripheral Nerve Regeneration. Journal of Biomedical Materials Research: Part A, 2011, 98A, 19-30.

2.  P. Ferruti, N. Mauro, A. Manfredi, E. Ranucci – Hetero-Difunctional Dimers as Building Blocks for the Synthesis of Poly(amidoamine)s With Hetero-Difunctional Chain Terminals and Their Derivatives. J. Polym. Sci. Part A: Polymer Chemistry, 2012, 50, 4947-4957.

3.  P. Ferruti, E. Ranucci, A. Manfredi, N. Mauro, E. Ferrari, R. Bruni, F. Colombo, P. Mussini, M. Rossi – L-Lysine and EDTA Polymer Mimics as Resins for the Quantitative and Reversible Removal of Heavy Metal Ion Water Pollutants. J. Polym. Sci. Part A: Polymer Chemistry, 2012, 50, 5000-5010.

4.  D. Maggioni, F. Fenili, L. D’Alfonso, D. Donghi, M. Panigati, I. Zanoni, R. Marzi, A. Manfredi, P. Ferruti, G. D’Alfonso, E. Ranucci – Luminescent Rhenium and Ruthenium Complexes of an Amphoteric Poly(amidoamine) Functionalized with 1,10-Phenanthroline. Inorganic Chemistry, 2012, 51, 12776-12788.

5. A. Manfredi,  E. Ranucci, S. Morandi, P.R. Mussini, P. Ferruti – Fast and Quantitative Manganese Sorption by Polyamidoamine Resins. J. Polym. Sci. Part A: Polymer Chemistry, 2013, 51, 769-773.

6. N. Mauro, A. Manfredi, E. Ranucci, M. Laus, D. Antonioli, C. Mantovani, V. Magnaghi, P. Ferruti – Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells. Macromolecular Bioscience, 2013, 13, 332-347.

7. D. Maggioni, P. Arosio, F. Orsini, A.M. Ferretti, T. Orlando, A. Manfredi, E. Ranucci, P. Ferruti, G. D’Alfonso. A. Lascialfari – Superparamagnetic Iron Oxide Nanoparticles Stabilized by a Poly(amidoamine)-rhenium Complex as Potential Theranostic Probe. Dalton Transactions, 2014, 43, 1172-1183.

8. P. Urbán, J.J. Valle-Delgado, N. Mauro, J. Marques, A. Manfredi, M. Rottmann, E. Ranucci, P. Ferruti, X. Fernàndez-Busquets – Use of Poly(amidoamine) Drug Conjugates for the Delivery of Antimalarials to Plasmodium. J. Control. Release, 2014, 177, 84-95.

9. M. Donalisio, E. Ranucci, V. Cagno, A. Civra, A. Manfredi, R. Cavalli, P. Ferruti, D. Lembo – Agmatine-containing poly(amidoamine)s as novel class of antiviral macromolecules: structural properties and in vitro evaluation of infectivity inhibition. Antimicrob. Agents Chemother., 2014, DOI:10.1128/AAC.03420-14.

10. N. Tonna, F. Bianco, M. Matteoli, C. Cagnoli, F. Antonucci, A. Manfredi, N. Mauro, E. Ranucci, P. Ferruti – A soluble biocompatible guanidine-containing polyamidoamine as promoter of primary brain cell adhesion and in vitro cell culturing. Sci. Technol. Adv. Mater., 2014, 15, 045007. DOI:10.1088/1468-6996/15/4/045007.

Graduated in Chemistry on 1982 at the University of Milan, appointed Researcher of the National Research Council on 1986, and Assistant Professor of Industrial Chemistry on 1992 at the Department of Organic and Industrial Chemistry (now merged into the Department of Chemistry). Her research activity has been focused, among others, on the asymmetric synthesis in biomimetic conditions (employing proteins, enzymes and cyclodextrins as chiral auxiliaries) or through the use of organometallic ligands; on the synthesis and characterization of chiral porphyrins to be used as catalysts in oxidation reactions; on the synthesis and characterization of macrocyclic and macropolycyclic receptors, and of new perfluorinated catalysts. Her present research interests are focused on the synthesis and characterization of a) biocompatible and biodegradable polymers for medical applications, to be used as: soluble or nanoparticulate carriers of antitumor, antiviral drugs or for gene therapy; b) biodegradable hydrogels as scaffolds for tissue engineering, and c) multifunctional cross-linked resins for the adsorption of heavy metal ions. She is co-author of more than 55 scientific publications in peer-reviewed International Scientific Journals, with an h-index of 14. She has been responsible lecturer of the courses of Organic Fine and Macromolecular Chemistry for the Bachelor degree in Applied and Environmental Chemistry (2002-2011) and of Safety in the Work and Chemical Instrumentations for the Bachelor degree in Industrial Chemistry (2000-2009). At present she teaches Laboratory of Industrial chemistry for the Bachelor degree in Industrial Chemistry, and Process Development for the Master degree in Industrial Chemistry.

 

TEN SELECTED PUBLICATIONS

1.  V. Magnaghi, V. Conte, P. Procacci, G. Pivato, P. Cortese, E. Cavalli, G. Pajardi, E. Ranucci, F. Fenili, A. Manfredi., P. Ferruti – Biological Performance of a Novel Biodegradabile Polyamidoamine Hydrogel as Guide for Peripheral Nerve Regeneration. Journal of Biomedical Materials Research: Part A, 2011, 98A, 19-30.

2.  P. Ferruti, N. Mauro, A. Manfredi, E. Ranucci – Hetero-Difunctional Dimers as Building Blocks for the Synthesis of Poly(amidoamine)s With Hetero-Difunctional Chain Terminals and Their Derivatives. J. Polym. Sci. Part A: Polymer Chemistry, 2012, 50, 4947-4957.

3.  P. Ferruti, E. Ranucci, A. Manfredi, N. Mauro, E. Ferrari, R. Bruni, F. Colombo, P. Mussini, M. Rossi – L-Lysine and EDTA Polymer Mimics as Resins for the Quantitative and Reversible Removal of Heavy Metal Ion Water Pollutants. J. Polym. Sci. Part A: Polymer Chemistry, 2012, 50, 5000-5010.

4.  D. Maggioni, F. Fenili, L. D’Alfonso, D. Donghi, M. Panigati, I. Zanoni, R. Marzi, A. Manfredi, P. Ferruti, G. D’Alfonso, E. Ranucci – Luminescent Rhenium and Ruthenium Complexes of an Amphoteric Poly(amidoamine) Functionalized with 1,10-Phenanthroline. Inorganic Chemistry, 2012, 51, 12776-12788.

5.       A. Manfredi,  E. Ranucci, S. Morandi, P.R. Mussini, P. Ferruti – Fast and Quantitative Manganese Sorption by Polyamidoamine Resins. J. Polym. Sci. Part A: Polymer Chemistry, 2013, 51, 769-773.

6.     N. Mauro, A. Manfredi, E. Ranucci, M. Laus, D. Antonioli, C. Mantovani, V. Magnaghi, P. Ferruti – Degradable Poly(amidoamine) Hydrogels as Scaffolds for In Vitro Culturing of Peripheral Nervous System Cells. Macromolecular Bioscience, 2013, 13, 332-347.

7.     D. Maggioni, P. Arosio, F. Orsini, A.M. Ferretti, T. Orlando, A. Manfredi, E. Ranucci, P. Ferruti, G. D’Alfonso. A. Lascialfari – Superparamagnetic Iron Oxide Nanoparticles Stabilized by a Poly(amidoamine)-rhenium Complex as Potential Theranostic Probe. Dalton Transactions, 2014, 43, 1172-1183.

8.     P. Urbán, J.J. Valle-Delgado, N. Mauro, J. Marques, A. Manfredi, M. Rottmann, E. Ranucci, P. Ferruti, X. Fernàndez-Busquets – Use of Poly(amidoamine) Drug Conjugates for the Delivery of Antimalarials to Plasmodium. J. Control. Release, 2014, 177, 84-95.

9.     M. Donalisio, E. Ranucci, V. Cagno, A. Civra, A. Manfredi, R. Cavalli, P. Ferruti, D. Lembo – Agmatine-containing poly(amidoamine)s as novel class of antiviral macromolecules: structural properties and in vitro evaluation of infectivity inhibition. Antimicrob. Agents Chemother., 2014, DOI:10.1128/AAC.03420-14.

N. Tonna, F. Bianco, M. Matteoli, C. Cagnoli, F. Antonucci, A. Manfredi, N. Mauro, E. Ranucci, P. Ferruti – A soluble biocompatible guanidine-containing polyamidoamine as promoter of primary brain cell adhesion and in vitro cell culturing. Sci. Technol. Adv. Mater., 2014, 15, 045007. DOI:10.1088/1468-6996/15/4/045007.