Clelia Giannini

FOTO Giannini

Assistant Professor of Organic Synthesis at DC UNIMI

Expertise  Organic Synthesis, NMR spectroscopy.

Graduated cum Laude, in 1996 at University of Naples, Dr Giannini received her Ph. D. in 2001 in “Sostanze Naturali Farmacologicamente Attive”, defending a thesis titled “Studi strutturali su composti bioattivi di origine marina e su proteine coinvolte in malattie genetiche”.

From 2000 to 2002 post-doc fellowship from the Medical Research Council (UK) to work in the NMR laboratory of Dr. Annalisa Pastore, Division of Molecular Structure, National Institute for Medical Research, Mill Hill, London; project: structural characterization of proteins involved in genetic diseases such as Frataxin and Ataxin I. From 2002 to 2004, post-doc position at Dipartimento di Chimica Organica e Industriale, Università di Milano, in professor Maiorana Group, and at Dipartimento di Chimica Inorganica, Metallorganica e Analitica, Università di Milano in Professor Renato Ugo Group; project: synthesis and characterization of peptide nucleic acids and heterohelicenes. From 2005 to present, permanent position as researcher in Organic Chemistry at Dipartimento di Chimica Organica e Industriale of University of Milan.

She is author of 29 peer-reviewed international publications.

Scientific activity:

a) Application of Ionic Liquids in organic chemistry as solvents and as liquid support for PNA synthesis;

b) synthesis and characterization of Peptide Nucleic Acids (PNA).

Ionic liquids have been successfully used as solvent for coupling between PNA monomers. Modified Ionic Liquids have been used as liquid support for oligomerization of PNA according to SILP (Supported Ionic Liquid Phase). Recently Dr. Giannini established a project aimed to synthesis of PNA able to form G-quadruplex structures; G-quadruplex are nucleic acid sequences that are rich in guanine and are capable of forming a four-stranded structure involved in many important biological processes. Further, the scientific projects carried out by Dr. Giannini have involved interdisciplinary competences and collaborations between different research groups.

 

SELECTED PUBLICATIONS

1). C. Baldoli, A. Bossi, C. Giannini, E. Licandro, S. Maiorana, D. Perdicchia, M. Schiavo, A Novel and Efficient Approach to (Z)-1,2-Bis(Benzodithienyl)Ethene Precursor of Tetrathia[7]elicenes, Synlett, 7, (2005) 1137.

2). C. Baldoli, P. Cerea, C. Giannini, E. Licandro, C. Rigamonti, S. Maiorana, The metal-Conjugated Peptide Nuclei Acid Challenge, Synlett, 13, (2005) 1984.

3). C. Baldoli, P. Cerea, L. Falciola, C. Giannini, E. Licandro, S. Maiorana, P. Mussini, D. Perdicchia, The electrochemical activity of heteroatom-stabilized Fischer-type carbene complexes, Journal of Organometallic Chemistry, 690, (2005) 5777.

4). E. Licandro, C. Rigamonti, M.T. Ticozzelli, M. Monteforte, C. Baldoli, C. Giannini, S. Maiorana, Synthesis and functionalization of novel tetrathia[7]helicenes as new push-pull systems, Synthesis, 21, (2006) 3670.

5). P. Cerea, C. Giannini, S. Dall’Angelo, E. Licandro, S. Maiorana, R. Marchelli , Synthesis of hydrazino-peptide nucleic acid monomers and dimers as new PNA backbone building blocks, Tetrahedron  63, (2007) 4108.

6). R. Ferraccioli, C. Giannini, G. Molteni, Stereoselective synthesis of 1,3-substituted tetrahydroisoquinolines through palladium-catalyzed three-component reaction, Tetrahedron: Asymmetry  18 (2007) 1475.

7). C. Xavier, C. Giannini, S. Dall’Angelo, L. Gano, S. Maiorana, R. Alberto, I. Santos, Synthesis, characterization, and evaluation of a novel 99mTc(CO)3 pyrazolyl conjugate of a peptide nucleic acid sequence, JBIC, Journal of Biological Inorganic Chemistry, 13 (2008) 1335.

8). F. Prischi, C. Giannini, S. Adinolfi, A. Pastore, The N-terminus of mature human frataxin is intrinsically

Unfolded, FEBS Journal, 276 (2009) 6669.

9). L. Poletti, C. Giannini, Ionic liquid mediated synthesis of peptide nucleic acids dimers, Tetrahedron 69 (2013) 1940.

10). G. Eidelshtein, S. Halamish, I. Lubitz, M. Anzola, C. Gannini, A. Kotlyar, Synthesis and Properties of Conjugates between Silver Nanoparticles and DNA-PNA Hybrids,  Journal of Self-Assembly and Molecular Electronics (SAME) 1 (2013) 69.